2017版栏目

关于空间结构学术沙龙第14期的通知

发布者：系统管理员发布时间：2017-01-03浏览次数：312

题目：Multiscale Modeling of Red Blood Cells and Beyond
             红细胞多尺度模拟
主讲人：彭张立博士
工作单位：圣母大学 航空与机械工程系
时间：2017年1月6日（星期五）上午10点
地点：安中大楼A326
报告简介：
Molecular mutations can lead to altered mechanical properties and malfunction of cells. However, it is a grand computational challenge to bridge the scales from molecules to cells. In this seminar, I will show examples of applying multiscale modeling to investigate red blood cell (RBC) diseases starting from the molecular scale. We considered the detailed molecular architectures of RBCs and predicted the bilayer-cytoskeletal interaction bond strength, which is crucial for understanding hereditary spherocytosis. Furthermore, we found that only mature sexual malaria-infected RBCs is transmittable because they can escape from the spleen clearance due to their low stiffness. This discovery may inspire new drug manipulations on malaria-infected RBC stiffness to disrupt malaria transmission. These findings have only become possible due to the multiscale modeling technique and the state-of-the-art understanding of molecular structures, and promise a new avenue to study the mechanics of biological systems.
彭张立博士简介：
彭张立博士于浙江大学土木工程系取得硕士学位，师从董石麟院士和袁行飞教授，随后在美国加州大学圣地亚哥分校获得博士学位，并在麻省理工学院攻读博士后，师从工学院院长SURESH院士。彭张立现任教于美国圣母大学(University of Notre Dame)航空与机械工程系，圣母大学在2016年的美国综合大学排名中，名列全美大学第15名。彭张立主要从事细胞力学，科学计算，新能源方面的研究。
 
欢迎广大师生参加！
空间结构研究中心


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